Gallbladder cancer is a rare cancer with approximately 5,000 cases diagnosed each year in the US. Patients typically present in their seventies with a 3 to 1 female predominance. Risk factors include gallstones, chronic cholecystitis, gallbladder polyps, calcified gall bladder, and typhoid carriers. Symptoms include weight loss, jaundice and cholecystis. Diagnosis and staging involve ERCP, liver MRI, or abdominal CT.
Treatment options include surgery, chemoradiation, adjuvant chemotherapy or chemotherapy alone. Chemotherapy agents include 5-FU, oxaliplatin, cisplatin, and gemzar.