Cholangiocarcinoma is also a rare cancer with approximately 5,000 cases diagnosed each year in the US. Patients are usually in theirs sixties. Risk factors include primary sclerosing cholangitis, hepatolithiasis, choledochal cysts, or liver fluke infection. Symptoms include weigh loss, jaundice, right upper quadrant pain, fever, and palpable mass. Diagnosis and imaging include liver MRI, MRCP, or abdominal CT. An ERCP is often needed for diagnosis.
Treatment options include surgery, adjuvant chemotherapy, chemoradiation, radiofrequency ablation or chemotherapy alone. Chemotherapy agents include 5-FU, oxaliplatin, cisplatin, and gemzar.